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DP00702 - Transcriptional coactivator YAP1

Organism Homo sapiens

Gene YAP1 (YAP65)

Sequence length 504

Disorder content 24.2%

Cross references UniProtKB:P46937, MobiDB:P46937

Dataset(s) NDDs-related proteinsCondensates-related proteins

Last update 2023-06-22

Entry history

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DP00702r008 Structural state

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Term disorder, IDPO:00076

Fragment 50 - 171

Evidence nuclear magnetic resonance spectroscopy evidence used in manual assertion, ECO:0006165

Cross references BMRB:27290

Reference ¹H, ¹³C, ¹⁵N resonance assignment of human YAP 50-171 fragment. Feichtinger M, Sára T, Platzer G, Mateos B, Bokhovchuk F, Chène P, Konrat R. Biomol NMR Assign, 2018, pmid:29372459

Statements Article "The very narrow peak dispersion in the 1H dimension of the 1H–15N HSQC spectrum shows that YAP 50–171 is intrinsically disordered."

Curator Erzsébet Fichó

validated by Federica Quaglia

DP00702r001 Structural state

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Term disorder, IDPO:00076

Fragment 101 - 171

Evidence X-ray crystallography-based structural model with missing residue coordinates used in manual assertion, ECO:0006220

Cross references PDB:3KYS

Reference Structural insights into the YAP and TEAD complex. Li Z, Zhao B, Wang P, Chen F, Dong Z, Yang H, Guan KL, Xu Y. Genes Dev, 2010, pmid:20123905

Statements Results "There is no electron density for residues 230–238 of TEAD and residues 101–171 of YAP, and therefore these were not built in the model."

Experimental details Toggle

Type	Name	External Links	Statements
Experimental components	interacting protein	Transcriptional enhancer factor TEF-1 UniProt:P28347

Curator Maria Cristina Aspromonte

validated by Victoria Nugnes

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DP00702 - Transcriptional coactivator YAP1