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DP01676 - Histone-lysine N-methyltransferase 2D

Organism Homo sapiens

Gene KMT2D (ALR, MLL2, MLL4)

Sequence length 5,537

Disorder content 1.3%

Cross references UniProtKB:O14686, MobiDB:O14686

Dataset(s) Cancer-related proteinsNDDs-related proteinsCondensates-related proteins

Last update 2023-08-26

Entry history

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DP01676r003 Structural state

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Term disorder, IDPO:00076

Fragment 4210 - 4280

Evidence far-UV circular dichroism evidence used in manual assertion, ECO:0006204

Reference Disordered Regions of Mixed Lineage Leukemia 4 (MLL4) Protein Are Capable of RNA Binding. Szabó B, Murvai N, Abukhairan R, Schád É, Kardos J, Szeder B, Buday L, Tantos Á. Int J Mol Sci, 2018, pmid:30400675

Statements Results "MLL4 4210–4280 has a more pronounced disorder tendency, as demonstrated by the IUPred profile and is devoid of any predicted ANCHOR binding sites (Figure 1E). Its sequence contains a significant portion of glutamines (Figure 1D), but it does not contain Q stretches longer than 4 residues. Far-UV CD measurements confirmed the disorder predictions,"

Curator Erzsébet Fichó

validated by Federica Quaglia

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DP01676 - Histone-lysine N-methyltransferase 2D